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Article |

Nephrotic Syndrome Following Topically Applied Sulfadiazine Silver Therapy

Charles J. Owens, MD; Dabney R. Yarbrough III, MD; Newton C. Brackett Jr., MD
Arch Intern Med. 1974;134(2):332-335. doi:10.1001/archinte.1974.00320200142021.
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A severely burned patient developed heavy proteinuria, hematuria, eosinophilia, and azotemia after receiving topical therapy with sulfadiazine silver. A renal biopsy specimen revealed interstitial nephritis and intramembranous electron-dense deposits in the glomerular basement membrane, suggesting an immune-complex mechanism of renal injury. Improved renal function and remission of proteinuria occurred after five months of therapy with immunosuppressive agents. Although renal injury following sulfonamide administration orally is well-known, there are, to our knowledge, no reports of the nephrotic syndrome in association with topical therapy with sulfonamides.


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