0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Pulmonary Aspects of Sickle Cell Disease

Philip A. Bromberg, MD
Arch Intern Med. 1974;133(4):652-657. doi:10.1001/archinte.1974.00320160146013.
Text Size: A A A
Published online

Patients with sickle cell disease are commonly hospitalized for acute, febrile pulmonary episodes that in children are generally due to severe infection. Vascular occlusion and infarction are more common in older age groups and may coexist with infection. Pneumococci are frequently the responsible infectious agent. Overwhelming bloodstream invasion and meningitis may occur due to impaired function of the spleen, the serum properdin system, and of neutrophils. Prophylaxis with penicillin has been advocated and immunization with polyvalent pneumococcal capsular vaccines is under study. Pulmonary infection and vascular occlusion with infarction are difficult to differentiate. The probably nonthromboembolic nature of the vascular occlusive process and the increased incidence of serious bleeding in sickle cell disease make anticoagulation or fibrinolytic therapy of dubious value. In some patients, widespread pulmonary vascular occlusion produces chronic pulmonary hypertension and cor pulmonale.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();