Early splenectomy for hypersplenism was performed on 50 patients with chronic lymphocytic leukemia (CLL), lymphosarcoma leukemic reticuloendotheliosis (LRE), reticulum cell sarcoma (RCS), and Hodgkin disease. Postoperative complications were infrequent. However, the effect of splenectomy on survival cannot be determined because no control study was done. Patients with CLL, LRE, and well-differentiated lymphosarcoma generally did better than those with RCS, poorly differentiated lymphosarcoma, and Hodgkin disease. Early splenectomy is recommended in CLL, LRE, and well-differentiated lymphosarcoma once hypersplenism has developed. It also is indicated in Hodgkin disease and hypersplenism but it should be recommended with caution in RCS and poorly differentiated lymphosarcoma.