0
ARTICLE |

Vincristine Neurotoxicity and Abnormal Secretion of Antidiuretic Hormone

Gary L. Robertson, MD; Nirmala Bhoopalam, MD; Leo J. Zelkowitz, MD
Arch Intern Med. 1973;132(5):717-720. doi:10.1001/archinte.1973.03650110061013.
Text Size: A A A
Published online

The secretion of the antidiuretic hormone, arginine vasopressin, has been studied in a patient who developed peripheral neuropathy and the syndrome of inappropriate antidiuresis during therapy with vincristine sulfate. The patient's plasma arginine vasopressin concentration, determined by a radioimmunoassay technique, was markedly increased despite profound hyponatremia and rose even higher following correction of the electrolyte imbalance. In six other vincristine-treated patients, in whom neither neuropathy nor inappropriate antidiuresis was observed, plasma arginine vasopressin concentration was in the normal range. These findings indicate that the inappropriate antidiuresis, which can occur during vincristine therapy, is associated with an abnormal increase in arginine vasopressin secretion. This complication appears to be related to the other neurotoxic effects of the drug and may be due to an alteration in the normal osmoreceptor control of vasopressin secretion.

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();