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Possible NZB Syndrome in Man

Martin M. Oken, MD; Robert W. Griffiths, MD; Ralph C. Williams Jr.; Bernhard E. F. Reimann, PhD
Arch Intern Med. 1973;132(2):237-240. doi:10.1001/archinte.1973.03650080081015.
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Considerable attention has been directed recently to the clinical and laboratory parallels between the autoimmune disease of New Zealand black (NZB) mice and that of human systemic lupus erythematosus (SLE).1-4 The two disorders often manifest similar laboratory and pathological findings; eg, serum anti-nuclear antibody, positive results of LE cell tests, Coombs test-positive hemolytic anemia, and renal or other parenchymal lesions compatible with an immune vasculitis. Evidence suggesting a pathogenetic role for virus has been presented in both instances and has been recently reviewed.5 Moreover, NZB mice have been shown to develop terminal lymphoproliferative disorders in a substantial percentage of instances.6-8 The case report presented here provides an interesting example of a human counterpart, or perhaps mirror image, to the clinical course of some mice afflicted with the NZB syndrome. Although the clinical and laboratory similarities between the NZB syndrome and SLE or malignant lymphoma in man constitutes an


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