We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Antithymocyte Antisera Globulin Effect on Human Lymphoid Neoplasia

Bernard Pirofsky, MD; Raymond Beaulieu, MD; Robert D. Goldman, MD
Arch Intern Med. 1973;132(2):171-174. doi:10.1001/archinte.1973.03650080019004.
Text Size: A A A
Published online

Six patients with preexisting lymphoproliferative neoplastic diseases received purified antithymocyte antisera globulin. A mean dose of 1,784 mg was administered over a mean period of 54 days. Beneficial therapeutic effects on associated immunologically mediated diseases were seen in two of the four patients with such abnormalities. There was no evidence of a therapeutic response with this agent on the neoplastic process, although the white-blood cell count transiently fell in a single case of chronic lymphocytic leukemia. Severe immunodepression was created in all subjects. In spite of this, there was no suggestion of either tumor spread or accentuated neoplastic growth following therapy with this drug. Two subjects, who have been followed up for 24 and 43 months, respectively, since therapy, manifested no evidence of a detrimental effect on the malignant process.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.