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Melkersson-Rosenthal Syndrome, Hodgkin Disease, and Corneal Keratopathy

John J. Mulvihill, MD; Walter W. Eckman, MD; Joseph F. Fraumeni Jr., MD; Robert M. Dryden, MD; Robert C. Young, MD
Arch Intern Med. 1973;132(1):116-117. doi:10.1001/archinte.1973.03650070102017.
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The Melkersson-Rosenthal syndrome consists of recurrent swelling of the lip or face, intermittent facial nerve palsy, and furrowed tongue.1,2 Most authors agree that the presence of any two of these three manifestations permits the diagnosis, more commonly reported from Europe than the United States. The possibility that the syndrome predisposes to Hodgkin disease is suggested by one previously reported case.3 We report the second patient with this syndrome who has developed Hodgkin disease and describe the occurrence of an unusual lesion of the cornea.

Patient Summary  A 63-year-old woman (NIH 08-64-39) was referred for therapy of Hodgkin disease, stage IIIB. The diagnosis had been made by inguinal node biopsy, following a five-months history of weight loss, falling hair, and dry scaling skin. A congenital left ptosis with associated amblyopia ex anopsia was surgically repaired in childhood.Drawing of corneal lesion as seen by slit-beam illumination. Slit-beam is


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