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Primary Hyperparathyroidism Presenting as a Giant Cell Tumor of the Maxilla

James L. Males, MD; William J. Howard, MD; Dennis R. Mask, MD; John L. Townsend, MD; James B. Snow Jr., MD; Harry T. McPherson, MD
Arch Intern Med. 1973;132(1):107-111. doi:10.1001/archinte.1973.03650070093015.
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Two cases of primary hyperparathyroidism presented as giant cell tumors of the maxillary sinus. The presence of hypercalcemia and multiple skeletal lesions appear to be the major distinguishing points among lesions with very similar histologic appearances: fibrous dysplasia, reparative giant cell granuloma, true giant cell tumor, and brown tumor of hyperparathyroidism. The clinical pattern in these two cases were similar, with the rather rapid development of symptoms and postoperative, transient tetany, which occurred during the period when bone remineralization was underway. The maxillary tumor became calcified in one instance, and responded dramatically to teletherapy with radioactive cobalt (60Co) in the other.


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