This symposium issue consists of ten reviews of subjects of great current interest in the general field of renal pathophysiology. They range in scope from the extensive review of phosphate and calcium excretion, by Massry et al to the summary of glucose reabsorption by Kurtzman and Pillay. All the authors have tried to relate the formulation of the physiologic observations they have reviewed to the characteristics of clinical entities. A thorough understanding of physiology is fundamentally important in the effective management of clinical problems in nephrology.
The first communication, by Klahr and Slatopolsky, deals with the large number of studies that continue to be conducted on the control of sodium reabsorption. They cite the contributions that, in part, led to the innovative use of diuretic agents in nonedematous states described by Martinez et al.
The mechanisms responsible for the concentration and dilution of the urine are still the source of