This book discusses developments in methodology in a technique that may have increasing application and utility in evaluating the effects of drugs on tissue: in vitro testing of drugs on cells derived from tissue culture.
The capabilities, advantages, limitations, problems, and potentialities of these in vitro techniques are discussed in a general way in the first two chapters. The remaining five chapters (80% of the book) are devoted to a discussion and critique of a large number of reports in this field derived from over 1,000 references selected from the world literature, spanning the last 50 years. A wide range of drug categories is covered, including anticancer and antimicrobial substances, steroids and anti-inflammatory drugs, and a large number of miscellaneous agents.
Since most of the book consists of detailed discussions of cell culture techniques and experimental results, it would be of little value to the general reader. However, to