This monograph on Nephron Failure is one in a series of American Lectures in Living Chemistry, edited by I. Newton Kugelmass. The title and subtitles, "Conservation, Substitution and Replacement" fairly well define the approach to the problem as presented by Dossetor. The authors purport to give us a perspective to the three phases of treatment of patients with chronic renal failure, ie, conservation, substitution by dialysis, or replacement by renal allograft. The book is directed to all those who share the care of patients with renal failure. I am in complete accord with their thesis that "informed collaborative coordination" should be the principle that underlies the many-faceted management of patients who have experienced kidney failure, as is the avowed aim of their monograph.
Their approach to early phases of such diseases as glomerulonephritis emphasizes the critical need for immunofluorescence and electron microscopy, suggesting that the internist or practitioner whose patient