0
ARTICLE |

Toxic Effects of Aerosol Propellants on the Heart

Willard S. Harris, MD
Arch Intern Med. 1973;131(1):162-166. doi:10.1001/archinte.1973.00320070158018.
Text Size: A A A
Published online

Contrary to their reputation as being inert, aerosol fluoroalkane propellant gases (Freons) are rapidly acting and potent cardiac toxins. This discovery, first made in mice, has been confirmed during adequate oxygenation, either in vitro or in vivo, in rats, cats, dogs, monkeys, and man. This brief review demonstrates that propellant gases are toxic to the mouse heart, enter the blood after inhalation, and, despite adequate oxygenation, quickly cause ventricular tachyarrhythmias in monkeys and lower arterial pressure and peripheral resistance in several species, and are directly toxic to ventricular myocardium, profoundly depressing its contractility in all species studied, including man. Ventricular tachyarrhythmias, bradyarrhythmias, acute heart failure, arterial hypotension, and asphyxia may cause sudden death in youths who deliberately inhale aerosol propellants. The possibility that these gases are harmful, acutely or chronically, to frequent aerosol users requires further study.

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();