We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Red Blood Cell Osmotic Fragility After Aortic Valve Replacement

Elaine Eyster, MD; John Rothchild, MD; Olga Mychajliw, AAS
Arch Intern Med. 1972;130(3):327-330. doi:10.1001/archinte.1972.03650030015004.
Text Size: A A A
Published online


Red blood cell osmotic fragility and autohemolysis studies were performed on 35 patients with aortic ball-valve prostheses. Osmotic fragility on fresh heparinized blood was normal. After 24 hours' incubation, it was increased in 17 patients. The most common abnormality was a "tail" of cells with increased fragility indicative of a heterogeneous population of cells. Sixteen patients with increased fragility had cloth-covered Starr-Edwards prostheses; the majority had intravascular hemolysis. Nine patients with normal fragility had Cutter or Magovern prostheses; the majority had minimal hemolysis. Autohemolysis after 48 hours' incubation with glucose was normal in all patients. Increased incubated osmotic fragility frequently reflects damage to red blood cells by prosthetic heart valves, and increased osmotic fragility is often associated with increased rates of hemolysis in vivo. The damage is greater with cloth-covered Starr-Edwards than with Magovern or Cutter prostheses.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.