This monograph is primarily a review and analysis of the hospital records of 248 patients with osteomyelitis seen at the Massachusetts General Hospital from 1963 through 1966.
Since most osteomyelitis is caused by Staphylococcus aureus, these dates are significant because essentially all of the effective and useful antistaphylococcal antibiotics (save for a few recently added analogues) were available during this period. It is also important to note that this four-year interval was well past the period of greatest prevalence and "invasiveness" of the staphylococci which was associated with the worldwide pandemic of infections with the virulent 80/81 and related phage types that had been dominant during much of the previous decade. Serious staphylococcal infections have decreased markedly in incidence during the period covered by this analysis. They have continued to decrease as less virulent staphylococci of new phage types and patterns with greater range of antibiotic susceptibility have superceded the