The topics which characterize each annual volume of the Annual Review of Pharmacology are a somewhat delayed reflection of the currency of a topic.
For example, recently there has been an increased concern with biologic rhythm. This is quite a change from a report in the New York Times in 1961 in which an otherwise able writer reported as "the most spectacular scientific non sequitur" the development of cancer in cockroaches whose day-night biological cycle had been severely disturbed. In regard to drug use in connection with biological rhythm there is a chapter in this book on circadian chronopharmacology, in which there is an account of the susceptibility to drug action related to the time of the circadian cycle during which a drug may be administered. The aim of chronopharmacology, as given by the authors is "... potentiation of desirable effects and minimizing undesired ones by the timing of drug administration...."