0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

"WHEEL SPINNING" ACUTE LEUKEMIA VS "SMOLDERING LEUKEMIA"

George A. Omura, MD
Arch Intern Med. 1972;129(3):500-501. doi:10.1001/archinte.1972.00320030120019.
Text Size: A A A
Published online

To the Editor.  —In regard to the interesting report by Knospe and Gregory on "Smoldering Acute Leukemia" (Arch Intern Med127:910-918,1971). I would like to suggest the alternative interpretation that at least in some instances, seemingly indolent leukemia may represent "wheel spinning" rather than "smoldering." It should be apparent that the population kinetics of this disorder must be rather unusual. Either the cells proliferate very slowly or they proliferate at usual or even supranormal rates, but have a high spontaneous death rate, resulting in little net growth of the disease.Clarkson et al1 have studied the cell kinetics of a similar patient, and found that the leukemic cells were in fact rapidly proliferating. This patient, in his 70s, subsequently had a one year remission after treatment.Thus, the smoldering leukemics should be carefully studied, not only as Knospe and Gregory have done, but also in regard to their

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();