0
ARTICLE |

Effect of Pharmaceutical Formulation on Gastrointestinal Bleeding From Aspirin Tablets

Jack R. Leonards, MD, PhD; Gerhard Levy, Pharm D
Arch Intern Med. 1972;129(3):457-460. doi:10.1001/archinte.1972.00320030077008.
Text Size: A A A
Published online

Gastrointestinal blood loss due to aspirin can be minimized by administering the drug as a dilute solution of acetylsalicylate. Bleeding can be prevented in normal subjects by adding sufficiently large amounts of antacids to the solution. These concepts have been applied to the formulation of very rapidly dissolving, highly buffered aspirin tablets. Daily oral administration of 2.6 gm of aspirin for seven days to 15 normal adult volunteers resulted in an average daily blood loss of 2.3 ml (in excess of the 0.4 ml control value) when a nationally distributed brand of aspirin tablets was used. An experimental tablet preparation caused only 0.7 ml daily blood loss, a reduction of 69%. Similar results were obtained with highly buffered chewable tablets. There was an inverse rank-order correlation between buffer capacity and blood loss in the series of tablet preparations tested.

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();