We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

IgG-K-Multiple Myeloma With Hyperviscosity Syndrome—Response to Plasmapheresis

Robert E. Wolf, MD; Jack B. Alperin, MD; Stephan E. Ritzmann, MD; William C. Levin, MD
Arch Intern Med. 1972;129(1):114-117. doi:10.1001/archinte.1972.00320010118016.
Text Size: A A A
Published online


Serum hyperviscosity has been identified in a variety of pathological conditions, including macroglobulinemia (Waldenström), certain polyclonal gammopathies, and, rarely, multiple myeloma.1-9 The hyper-viscosity syndrome1-4 may lead to malaise, hemorrhagic diathesis, ocular disturbances, Ménière's syndrome, central nervous system dysfunction, or renal and cardiac abnormalities, depending upon the organs primarily affected. Plasmapheresis1,2,4,8,10-13 may be the only effective therapy. This report describes two patients with IgG-K multiple myeloma and severe hyperviscosity syndrome. Life-threatening manifestations of serum hyper-viscosity, hemorrhage in one patient, and bizarre neurological dysfunctions in the other responded to vigorous plasmapheresis.

Patient Summaries 

Patient 1.  —A 54-year-old Negro woman was admitted in January 1969 with a three-month history of low back pain, anemia, and a bone marrow determination compatible with multiple myeloma. There was mild arteriolar narrowing in the ocular fundi, tenderness over the lower thoracic and lumbar spine, pain on truncal movement, and generalized hyperactive reflexes. Findings of


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.