Postmeningitic Selective Hypopituitarism With Suprasellar Calcification

Barry M. Sherman, MD; Phillip Gorden, MD; Giovanni di Chiro, MD
Arch Intern Med. 1971;128(4):600-604. doi:10.1001/archinte.1971.00310220108017.
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The finding of suprasellar calcification in a young male with diabetes insipidus and selective anterior putuitary insufficiency suggests the presence of a craniopharyngioma. However, calcifications at the base of the brain are common in patients successfully treated for tuberculous meningitis1-5 and both pituitary insufficiency and precocious puberty have been described as sequelae to cured tuberculous meningitis.6-8

Haslam et al9 have recently reported a patient with suprasellar calcifications who developed diabetes insipidus, growth failure, and hypogonadism following the successful treatment of tuberculous meningitis. We have studied a patient with similar hormonal deficiencies and intracranial calcifications occurring several years after the successful treatment of tuberculous meningitis. A suprasellar mass and hydrocephalus were excluded as causes of the hormonal deficiencies. This case further documents localized involvement by the tuberculous process as the cause of the endocrine syndrome.

Patient Summary  A 17-year-old Potawatomi Indian boy was referred to the Clinical Center


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