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Article |

Pathogenesis of Diabetes Mellitus.

Shiao-wen Shen, MD
Arch Intern Med. 1971;128(2):314-315. doi:10.1001/archinte.1971.00310200150023.
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This volume is based on the Nobel Symposium held in Stockholm from Sept 3 to 6, 1969. The four introductory lectures have all been published elsewhere either in whole or in part. This is also true for most of the special lectures. However, there might be an advantage in having them assembled in one compact volume, especially to readers other than the small band of diabetologists who are actively engaged in diabetes research.

On the bright jacket it was stated that "the Symposium was aimed at indicating the route that research in the field of diabetes sooner or later would have to follow." The symposium falls somewhat short of this aim. The predominant theme is that disturbances of the dynamics of insulin secretion are the cause of diabetes mellitus. The sluggish response of beta cells to a glycemic stimulus is considered to be the initial, genetically brought-about expression of an


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