The clinical concept of the Goldblatt kidney began as an unplanned child, went through a stormy adolescence, and has now emerged, in its 35th year, as a serious and interesting adult. It is the purpose of this paper to provide brief sketches of those periods, to characterize the present situation, and finally to speculate about the future.
Goldblatt was a properly brought up young man, which is to say he had been taught that hypertension produced sclerosis of the large and small branches of the arterial system, including those of the kidneys, and that the cause of the hypertension was unknown. His experience as a pathologist, however, repeatedly confronted him with the fact that the hypertensive patient at necropsy showed vascular sclerosis in the kidney which was more frequent and severe than that seen in any other organ. It was possible that the renal vessels were more vulnerable to damage