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July 1971, Vol 128, No. 1 >
ARTICLE | July 1971

Ophthalmologic Manifestations of Sickle Cell Thalassemia

Morton F. Goldberg, MD; Samuel Charache, MD; Ireneo Acacio, MD
Arch Intern Med. 1971;128(1):33-39. doi:10.1001/archinte.1971.00310190037002.
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Vascular abnormalities were studied in the eyes of 14 patients with sickle cell thalassemia (S-thal). Angioid streaks were observed for the first time in a patient with S-thal. "Black sunbursts," which are seen more often in the fundi of patients with sickle cell anemia (SS disease) than in those with sickle cell hemoglobin C disease (Hb SC) were generally few in number in the fundi of patients with S-thal. Proliferative sickle retinopathy, which is much more characteristic of Hb SC than of SS disease, was seen in nine patients with S-thal. The retinas of S-thal thus resemble those of Hb SC more than SS. The hemoglobin composition of a patient's red blood cells can be predicted, to a degree, from the presence and type of certain retinal anomalies in sickling disorders. Overall clinical status is not usually as good as indicator of hemoglobin composition.

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