We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Cerebrospinal Fluid Glutamine as a Measure of Hepatic Encephalopathy

Benjamin T. Hourani, MD; Edwin M. Hamlin, MD; Telfer B. Reynolds, MD
Arch Intern Med. 1971;127(6):1033-1036. doi:10.1001/archinte.1971.00310180049005.
Text Size: A A A
Published online

To test the correlation between cerebrospinal fluid (CSF) glutamine level and hepatic encephalopathy, measurements were made in 86 patients. In 51 without liver disease, mean CSF glutamine level was 12.6 ± 5.1 mg/100 ml. In nine patients with liver disease but without clinical encephalopathy, the mean value was 21.6 ± 6.2 mg/100 ml and in 26 patients with varying degrees of precoma and coma it was 40.3 ± 14 mg/100 ml. There was a fair correlation between the severity of encephalopathy and the glutamine level. The CSF glutamine test, an easily performed biochemical evaluation, seems useful in the diagnosis of hepatic encephalopathy and in the assessment of its severity.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.