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Lecithin Biosynthesis in Cigarette Smoking Dogs

John A. Balint, MB, MRCP; Stuart Bondurant, MD; Emilios C. Kyriakides
Arch Intern Med. 1971;127(4):740-747. doi:10.1001/archinte.1971.00310160218018.
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The effects of acute exposure to cigarette smoke on the synthesis of lecithins in lung, pulmonary surfactant, heart, and liver were studied in anesthetized dogs after intravenous injection of 32PO4, cholinemethyl-3H and either methionine-methyl-14C, ethanolamine-1-2-14C, or palmitic acid1-14C. Control dogs and dogs exposed to heavy doses of smoke were anesthetized and ventilated with a positive pressure respirator through an endotracheal tube for 90 to 220 minutes after isotope injection. The pool size of lecithins was not changed by smoking, but statistically significant decreases in choline and phosphate incorporation were observed in the lecithins of lung and pulmonary surfactant and in the linoleoyl lecithin of the heart. No significant differences were noted in terms of isotope incorporation in liver, the phosphatidyl ethanolamines of any tissues, or in surface activity of lung extracts.


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