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Paul Oglesby, MD
Arch Intern Med. 1971;127(2):321-322. doi:10.1001/archinte.1971.00310140149034.
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This volume presents the Proceedings of the First International Symposium on Atherogenesis, Thrombogenesis, and Treatment with Pyridinol Carbamate held in Japan in May 1969 under the auspices of the Japanese Medical Association and the Japanese Arteriosclerosis Research Foundation. Included are 46 communications, some very brief; 37 are involved with the use of pyridinol carbamate. Most of the investigators are from Japan, and three of the communications are presented in French.

Shimamoto noted that following injection of an "atherogenic" agent (such as cholesterol) he could produce in the experimental animal an acute arterial injury with edema of the endothelial cells and subendothelial spaces and adherence of platelets and white blood cells to the injured region. Ishikawa and Shimamoto described how the drug pyridinol carbamate appeared to prevent such vascular injury and would even alter established lesions by the ingrowth of regenerated smooth-muscle fibers.

The various presentations suggested possible applications to human


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