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Acromegaly, Pheochromocytoma, Toxic Goiter, Diabetes Mellitus, and Endometriosis

G. Lance Miller, MD; James Wynn, MD
Arch Intern Med. 1971;127(2):299-303. doi:10.1001/archinte.1971.00310140127019.
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The association of pheochromocytoma and acromegaly has been described in three patients prior to the present report.1-3 Both diseases were recognized concurrently in only one of these cases.3 In the other two instances, they were recognized 15 and 20 years following therapy for acromegaly. Since 37% of acromegalics may have hypertension,4 the small reported incidence of pheochromocytoma may indicate that the association is not often considered. The case to be described clearly indicates the necessity for such consideration.

The occurrence of multiple endocrine disorders in association with acromegaly is established.5-8 Despite the recognized concurrence of several endocrinopathies in patients with acromegaly, thyroid disease, or pheochromocytoma, the association, in one patient, of five endocrine disorders is so striking that speculation on their possible common etiology seems warranted.

In addition to the unusual extent of multiple system involvement, the present case has been instructive in regard to certain


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