The republic of Vietnam is highly endemic for plague infections. With the volume and efficiency of air travel, this disease may occur in servicemen or civilians who return from this area. There was a wide spectrum of manifestations in six cases of proved and two of presumptive plague infection in patients hospitalized at the US Army Eighth Field Hospital. These cases occurred in persons of varied ethnic background. The features of the classic fatal bubonic-septicemic form were seen, as were cases difficult to distinguish from lymphogranuloma venereum. Treatment was effective in all but two cases. Continued awareness of this disease is emphasized, as early diagnosis and treatment are imperative.