Treatment of Renal Osteodystrophy With 25-Hydroxycholecalciferol

Hector F. DeLuca, PhD; Louis V. Avioli, MD
Arch Intern Med. 1970;126(5):896-899. doi:10.1001/archinte.1970.00310110166030.
Text Size: A A A
Published online

Vitamin D3 is converted by a liver enzyme system, calciferol-25-hydroxylase, to 25-hydroxycholecalciferol (25-HCC), the active hormonal form of the vitamin. This hydroxylase is feedback inhibited by 25-HCC, and probably represents an important physiologic control step for active vitamin D. The 25-HCC is further converted in intestine, kidney, and bone to two more polar metabolites which probably represent the metabolically active form of vitamin D3. Evidence has been presented that in uremia, excessive metabolism of vitamin D results in low plasma levels of 25-HCC. In chronically uremic rats, 25-HCC is at least one hundredfold more effective than vitamin D3 in restoring calcium absorption. In uremics, treatment with 10,000 international units (IU) of 25-HCC/day, improves calcium absorption, increases urinary and plasma calcium and decreases plasma alkaline phosphatase. Thus, 25-HCC may be the drug of choice in bone disease of uremia.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.