Louis V. Avioli, MD: I would like to point out the difficulty of comparing uremic syndromes of varying degrees and longevity. For instance, I think the fact that Dr. Fishman was unable to document Dr. Welt's observations may relate to the fact that Dr. Welt's studies were done on material obtained from patients with chronic uremia, rather than the acute uremia which follows bilateral nephrectomy. Acute nephrectomy very often leads to a decreased food intake which, in itself, may alter a variety of metabolic processes. I wonder if the control animals described in the first two papers were pair-fed.
Dr. Van Den Noort: Our control rats were starved for the same period of time that the nephrectomized were. Both were fed water only.
Dr. Fishman: Our nephrectomized rats were allowed 5% glucose in water ad lib and their weights were essentially unchanged 46 hours following nephrectomy, at the time they