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The Isoantigenic Systems of Human Leukocytes: Medical and Biological Significance.

A. S. Wiener, MD
Arch Intern Med. 1970;126(4):706. doi:10.1001/archinte.1970.00310100152032.
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This monograph is the sequel to the same author's previous 182-page book on Leukocyte Antigens and Antibodies. The previous book which appeared in 1960 contained 567 references, while the present monograph cites 404 references, all published after 1960. There is hardly any overlap between the two volumes. Judging from the large number of publications, this is a rapidly developing field, and Walford's new book is an excellent aid for those who wish to know present status of the subject.

It is much more difficult to carry out leukocyte typing than to type red blood cells (RBC) for two main reasons: (1) the yield of leukocytes from a specimen of blood is only about one-thousandth the yield of RBC, and (2) white blood cells do not form stable suspension such as RBC do. Therefore, serological studies on leukocytes have been hampered by the dirth of material with which to work, as


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