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Meningeal Myeloma

Jorge E. Maldonado, MD, PhD; Robert A. Kyle, MD; Jurgen Ludwig, MD; Haruo Okazaki, MD
Arch Intern Med. 1970;126(4):660-663. doi:10.1001/archinte.1970.00310100106014.
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We recently had a patient with multiple myeloma whose main clinical manifestations and direct cause of death were related to myeloma of the dura mater. Only five proved cases of myeloma limited to the meninges and independent of bone lesions have been reported.1-5 These five patients had no systemic evidence of multiple myeloma. We reviewed 110 complete autopsy cases of multiple myeloma and found no cases of independent meningeal involvement. In this communication we report our case and review the previously reported cases of meningeal myeloma.

Patient Summary  A 40-year-old woman was admitted to the Mayo Clinic in a lethargic and semi-stuporous state. The family history and the patient's medical history were noncontributory. She felt weak and had had several episodes of infection about six months before. Irritability and lethargy were present and she also complained of headaches and had menorrhagia. Anemia was found and a diagnosis of myeloma


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