In 1967, a conference on bile salt metabolism was held at the University of Cincinnati. Thirty-five of the most prominent investigators in this field presented a comprehensive review of the subject which is now published in book form. Clinicians and investigators will find it an important reference in understanding the role of bile salts in health and disease.
Identification of new bile salts and their conjugates from human bile as well as a new bile alcohol, from the most primitive of surviving vertebrates the lamprey, is described. Bile salt metabolism and the conversion from one salt to another is presented in detail for man and beast. There is a discussion of enzyme systems, and the rate-controlling effects of bile salts and their derivation from cholesterol. The clinical significance of the derivation of bile salts from cholesterol, and its relationship to atherosclerosis is intriguing. Considerable investigation is being carried out in