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Concepts and Models of Biomathematics: Simulation Techniques and Methods.

William R. Best, MD
Arch Intern Med. 1970;126(3):535. doi:10.1001/archinte.1970.00310090165043.
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The academically oriented clinician is used to thinking about normal and abnormal bodily function in terms of qualitative physiology and biochemistry; he is on shakier grounds when it comes to quantitation. Yet more precise insights into man's nature may be gained through careful recording of physiologic "outputs," after "inputs" to organs are perturbed, and then comparing such time-curves with simulations using computer trials of mathematical models. This volume, number one in a proposed series on biomathematics, explores such simulations of cellular glycolysis, mitochondrial electron transport (oxidation of reduced pyridine nucleotides and flavoproteins), blood glucose regulation, the neuroendocrine regulation of adrenal cortisol secretion, and other selected biologic systems. Each topic is introduced with a succinct review of our current understanding of its biochemistry and physiology. The approach to and results of simulation using digital or analog computers is then elaborated. A number of useful hints to the simulationist are to be


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