This summary was prepared to share with a broader audience some of the observations and concepts developed during the workshop and to discuss certain implications of these which in our opinion may be useful to colleagues for future experiments. The summary contains three topics: (1) the pathobiology of cell systems in the lung (2) types of models, and (3) relevance of model systems to man.
Pathobiology of the Lung
The primary response to inhaled materials is found at the cell level with later changes in physiological functions such as pulmonary clearance and airway dynamics. Modern techniques have made it possible to detect these changes at the subcellular levels as ultrastructural or biochemical changes which may alter the functions of cells as biochemical synthesis systems, energy transfer systems, and proliferating populations.The knowledge is still incomplete concerning the types of cells in the lungs, their functions and the materials being