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The Canine Tracheal-Pouch Model

Joe R. Wardell Jr., PhD; Lawrence W. Chakrin, PhD
Arch Intern Med. 1970;126(3):488-490. doi:10.1001/archinte.1970.00310090118014.
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A canine model is described in which a segment of the cervical trachea is separated and formed in situ into a subcutaneously buried pouch. Some of the possible applications of the canine tracheal-pouch model to studies on inhalation toxicity are the following: (1) the separation of direct from reflex-induced effects of irritants on respiratory airway tissue in situ, (2) the study of various factors believed to be involved in the pathogenesis of mucus hypersecretion states (both independently and in relation to one another), and (3) the correlation of possible changes in chemical composition and physical properties of mucus secreted in response to irritants with histological and histochemical changes in the mucus-secreting structures in situ.


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