0
ARTICLE |

Evaluation of Model Systems for Study of Airway Epithelium, Cilia, and Mucus

Lynne Reid, MD
Arch Intern Med. 1970;126(3):428-434. doi:10.1001/archinte.1970.00310090058006.
Text Size: A A A
Published online

An animal "model" of human lung disease provides a means of testing the effect of irritants and of study in pathogenesis. To relate the model to human lung disease it is necessary to establish the morbid anatomy of the disease. The airway lining system which is under scrutiny here is a. mucus-secreting surface appropriate for the study of chronic bronchitis, the main features of which in man are hypertrophy of mucus-secreting cells, increase in number of goblet cells and extension to the periphery, and an increase in cell activity. The mitotic count is raised and the type of acid glycoprotein modified. These changes can be quantified. They can be reproduced in the experimental animal. The rat is chiefly dealt with here as it has been studied in most detail.

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();