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Progress in Allergy.

Robert E. Reisman, MC
Arch Intern Med. 1970;125(4):735-736. doi:10.1001/archinte.1970.00310040159034.
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As has been the custom in this series, selected timely topics related to the field of hypersensitivity are reviewed by competent authorities. In this newest edition six subjects are covered, with stress laid upon fundamentals of immunopathogenesis.

Three of the chapters deal with topics of broad interest and deserve particular mention. The "Metabolism of Immunoglobulins" by Waldemann and Strober is a critical and practical review of an area of increasing importance. Included are discussions of normal immunoglobulin metabolism and the relationship of abnormalities of metabolism to pertinent clinical problems. Unfortunately, gamma E globulin, newly defined and small in quantity, is not included in these studies.

"Immunological Reactions Involving Two Cell Types" is the title of the chapter by Coombs and Franks. This is a very complete, exceedingly well-written review. Included are practical discussions of mixed agglutination and mixed antiglobulin reactions and cytophilic antibodies. Liberal use is made of simplified diagrams


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