Research and Clinical Studies in Headache: An International Review, vol 2.

This second volume of an international review, contains a wealth of fascinating and thought-provoking material for all physicians who think of headache and migraine as a true clinical and intellectual challenge. The quality of the papers is uniformly superior and reflects as much credit upon its authors as upon the editor who has a well-earned reputation as one of the world leaders in the study of headache.

The paper by Heyck deals with blood gases and circulatory studies of cerebral hemodynamics and offers some exciting clues to the pathogenetic mechanisms of the migraine attack. Anthony and his collaborators demonstrate that a decrease in plasma serotonin is associated with the onset of the migraine attack and may, therefore, be responsible for initiating the vascular changes. In an interesting and a much overdue study, Bianchine and Eade conclude that no clear cut interrelationship can be established between certain vasoactive substances such as