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Low CSF Glucose Level in Sarcoidosis Involving the Central Nervous System

J. David Gaines, MD; Paul B. Eckman, MD; Jack S. Remington, MD
Arch Intern Med. 1970;125(2):333-336. doi:10.1001/archinte.1970.00310020139021.
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Sarcoidosis, a systemic granulomatous disease of undetermined etiology and pathogenesis,1 may involve multiple organs and produce a wide spectrum of clinical manifestations.2,3 The nervous system is not commonly affected,4-6 but when it is, neurologic manifestations are protean. Recently Siltzbach outlined the clinical features observed in 311 cases of sarcoidosis diagnosed at the Sarcoidosis Clinic at the Mount Sinai Hospital in New York from 1946 to 1961.7 Four of the patients experienced a mode of onset referable to the nervous system, and 13 (4%) had evidence of nervous system involvement sometime during the course of their disease.

Although there are a number of publications which describe the neurologic manifestations of sarcoidosis,6,8 we were unable to find a review of the changes which occur in the cerebrospinal fluid (CSF) in this entity. Sarcoidosis is rarely considered in the differential diagnosis of low CSF glucose, probably because most


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