Pancreatic Insufficiency and Neutropenia With Associated Immunoglobulin Deficit

Edsel Hudson, MD; Thomas Aldor, MB, BS, MRACP
Arch Intern Med. 1970;125(2):314-316. doi:10.1001/archinte.1970.00310020120017.
Text Size: A A A
Published online

Recent reports have called attention to the association of pancreatic insufficiency and bone marrow dysfunction in children.1-7 This syndrome, although uncommon, is thought to represent the major disorder of pancreatic dysfunction in childhood when cystic fibrosis is excluded. We have recently evaluated such a patient in whom the significance of the association was not realized until adolescence and who was also found to have immunoglobulin deficiencies.

Patient Summary  A 16-year-old white boy was admitted to the hospital in 1966 for evaluation of previously diagnosed pancreatic insufficiency. He was born at eight months' gestation and weighed 3,281 gm (5 lb 4 oz). His first teeth appeared when he was 7 months old and he walked at 21 months of age. The patient was thought to have celiac disease during his first year when he was found to be anemic and to have bulky, foul-smelling stools. It was also reported that


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.