We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Angiotensin and Aldosterone in Renovascular Hypertension

Theodore A. Kotchen, MD; Bernard Lytton, MD; Lewis B. Morrow, MD; Patrick J. Mulrow, MD; Peter M. Shutkin, MD; H. C. Stansel, MD
Arch Intern Med. 1970;125(2):265-272. doi:10.1001/archinte.1970.00310020071006.
Text Size: A A A
Published online


The renin-angiotensin-aldosterone system was studied in patients with renovascular hypertension. When a liberal sodium diet was used, aldosterone excretion rate was increased in four of 14 patients with benign hypertension, who subsequently improved postoperatively. Aldosterone excretion rate was measured in six patients following surgery, and the values were lower than preoperative values in all six. Aldosterone secretion rate tended to be slightly higher in patients who improved postoperatively than in those who did not improve. Both the excretion and secretion rates were elevated in all five patients with malignant hypertension. The level of arterial angiotensin was normal in all patients with renovascular hypertension in whom it was measured. These findings indicate that if the activity of the renin-angiotensin-aldosterone system is increased, this increase is subtle and difficult to demonstrate. Consequently it is unlikely that the blood pressure elevation in patients with benign renovascular hypertension can be explained simply in terms


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.