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The Syndrome of Inappropriate Antidiuretic Hormone Secretion An Unusual Case

Donald R. Olson, MD; George C. Buchan, MD; George A. Porter, MD
Arch Intern Med. 1969;124(6):741-747. doi:10.1001/archinte.1969.00300220093018.
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The syndrome of inappropriate antidiuretic hormone (SIADH) secretion is being recognized with increasing frequency particularly in association with tumors which secrete antidiuretic hormone (ADH), notably, bronchogenic carcinoma. In many of the tumor-related cases, increased amounts of polypeptide with ADH properties have been measured in the serum, urine, or tumor extracts by bioassay or immunoassay. In other instances, the presence of increased antidiuretic hormonal activity has been shown by careful metabolic balance studies. This syndrome also has been demonstrated in a variety of nonneoplastic states, but microscopic changes in the hypothalamic-neurohypophyseal tract have been described only once.1 Furthermore, tumor-related cases with involvement in this area of the brain have rarely been reported, and such cases show destruction limited to the posterior lobe of the pituitary gland, indicating that this structure, per se, is not necessary for ADH formation.2,3

This communication describes a unique instance of adenocarcinoma of the lung,


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