Systemic lupus erythematosus (SLE) has become a frequently recognized common denominator in seemingly unrelated diseases. This communication deals with a patient in whom SLE appeared to have been an underlying factor in several diseases which occurred over a 25-year period. She had a childhood nephritis and in adult life was plagued by the signs and symptoms of Hodgkin's disease, polyarthritis, and recurrent nephritis. Amenorrhea and galactorrhea developed post partum. She also had an acute nonsuppurative thyroiditis which was followed by an autoimmune thyroiditis. Systemic lupus erythematosus was diagnosed at this time. Finally, the thyroiditis, nephritis, polyarthritis, galactorrhea, and amenorrhea were relieved, and the positive lupus test became negative after long-term treatment with prednisone.
A 29-year-old white woman was referred to Memorial Hospital in November 1962 because of Hodgkin's disease. Rheumatoid arthritis and Hodgkin's disease were diagnosed in February 1959, when the patient was admitted to another hospital because