The Intracellular Biosynthesis of Collagen:  Some Possible Implications for Diseases of Bone and Other Connective Tissues

Darwin J. Prockop, MD, PhD
Arch Intern Med. 1969;124(5):563-570. doi:10.1001/archinte.1969.00300210045006.
Text Size: A A A
Published online

The work performed in this laboratory in the last several years bears only indirectly on the subject of this symposium, but it probably provides a basic framework for biochemical approaches to the problems which occur in bone as a result of long-term dialysis. Collagen is the principal organic constituent of bone, and one of the questions we and others have asked is 1: How do cells in connective tissue synthesize collagen? Before discussing this question, however, I will present a brief review of the structure of the collagen molecule as it is known.2-5

Structure of Collagen  The collagen fibers in connective tissues are made up of small fibrils which have a characteristic pattern when examined by electron microscopy (Fig 1). The most characteristic feature of these fibrils is a series of major crossbands which are separated by a distance of approximately 700 Angstroms (A). As was demonstrated primarily


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.