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Urinary Parathyroid Hormone-Like Activity in Patients With Uremia

John E. Bethune, MD; Zaven H. Chakmakjian, MD; Randolph A. Turpin
Arch Intern Med. 1969;124(4):423-425. doi:10.1001/archinte.1969.00300200035006.
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It has been known for many years that there is a substance in the urine of patients with primary hyperparathyroidism that behaves biologically like parathyroid hormone (PTH).1 We have developed a procedure for extracting this material from urine and bioassaying it in mice.2

This technique has now been applied to the extraction and concentration of PTH-like material from the urine of patients with uremia, with the use of a concentration procedure (Sephadex). We first measured its presence in a group of patients with uremia and then attempted to identify the nature of the material found. Figure 1 shows the bioassayable PTH-like activity found in 24-hour urine samples from 9 patients with uremia compared to that found in 20 normal subjects and in 18 patients with primary hyperparathyroidism. In the normal subjects, there was either no detectable PTH-like activity or only a very slight amount. In patients with uremia,


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