Adrenal Insufficiency and Inappropriate Secretion of Antidiuretic Hormone:  Occurrence in a Patient With Carcinoma of the Lung

Morris Schambelan, MD; Paul E. Slaton Jr., MD; John F. Murray, MD; Edward G. Biglieri, MD
Arch Intern Med. 1969;124(2):197-201. doi:10.1001/archinte.1969.00300180069013.
Text Size: A A A
Published online

In recent years a syndrome has been described 1,2 in which hyponatremia and renal loss of sodium have been attributed to the overexpansion of body fluids resulting from the inappropriate secretion of antidiuretic hormone (ADH). The majority of cases occur in patients with carcinoma of the lung,3 but the syndrome is also associated with other diseases including porphyria,4 myxedema,5 and a variety of disorders of the central nervous system.6 The characteristic features of this syndrome are hyponatremia and hypotonicity of body fluids, continued renal excretion of sodium, urine osmolality greater than that appropriate for concomitant tonicity of plasma, normal renal and adrenal function, and correction of both hyponatremia and urinary sodium loss by fluid restriction.7,8 Recognition of this syndrome is rarely difficult, although patients with adrenal insufficiency may have similar clinical manifestations. While careful evaluation of adrenal function usually differentiates between these disorders, Bartter and


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.