Familial Cold Urticaria:  A Generalized Reaction Involving Leukocytosis

John P. Tindall, MD; Sharon K. Beeker; Wendell F. Rosse, MD
Arch Intern Med. 1969;124(2):129-134. doi:10.1001/archinte.1969.00300180001001.
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Studies of a family with "familial cold urticaria" indicate that the syndrome is not a true urticarial disorder, but appears to be a systemic reaction generated by cooling of the skin. The systemic reaction appears to be mediated by an unidentified humoral substance, probably not histamine. Leukocytosis is a constant accompaniment of the generalized reaction and seems to play a role in the pathogenesis of the skin lesions. The generalized reaction can be prevented by the prior administration of Pseudomonas polysaccharide complex (Piromen).


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