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ARTICLE |

Blood Glucose and Gluconeogenesis in Fasting Man

Philip Felig, MD; Errol Marliss, MD; Oliver E. Owen, MD; George F. Cahill Jr., MD
Arch Intern Med. 1969;123(3):293-298. doi:10.1001/archinte.1969.00300130075011.
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Maintenance of blood glucose homeostasis in fasting man requires establishment of a fine balance between glucose production and utilization. Early in starvation, a decrease in serum insulin provides the alterations in substrate concentration and enzymatic activity conducive to augmented gluconeogenesis. As fasting progresses, glucose utilization is reduced as the brain consumes ketone bodies. A concomitant reduction in total gluconeogenesis is brought about by a reduction in plasma amino acid levels, particularly alanine.

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