This monograph contains 197 pages with 217 references. It consists of four parts. The first is an introduction which gives a clear discussion of the nomenclature of the globulins, M-component paraproteins, and the clinical importance of monoclonal vs polyclonal hypergammaglobulinemias. Eight pages are devoted to the diagnostic importance of the erythrocyte sedimentation rate.
The second part contains a discussion of the monoclonal hypergammaglobulinemias. This includes the incidence of reticuloendothelial malignancies associated with monoclonal globulinopathies, metabolic derangements associated with multiple myeloma, characterization and significances of the cryoglobulins, euglobulins, and cold agglutinins. Eleven pages are devoted to the differentiation between monoclonal essential hypergammaglobulinemia and myeloma. The discussion concerning the concepts of homogeneous monoclonal and biclonal globulin production appeared confusing.
The third portion of the monograph is devoted to the polyclonal hypergammaglobulinemias. In this section, Waldenstrom discusses the relationship of "autoimmune" diseases to polyclonal hyperglobulinemias, serological effects of polyclonal hyperglobulinemia, the relationship between