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February 1969, Vol 123, No. 2 >
ARTICLE | February 1969

Treatment of AGL

Stanley L. Lee, MD; Fred Rosner, MD; William H. Crosby, MD
Arch Intern Med. 1969;123(2):205-207. doi:10.1001/archinte.1969.00300120093017.
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ABSTRACT

To the Editor.  —The editorial by William H. Crosby, MD, "To Treat or Not to Treat Acute Granulocytic Leukemia" (Arch Intern Med122: 79-80 [July] 1968), prompts the following comments.The decision whether or not to treat intensively a given patient with acute granulocytic leukemia (AGL) is indeed a difficult one. In his editorial, Dr. Crosby attempts to resolve the problem by listing a series of six variants of AGL in which "the remission rate is zero," and in which, therefore, treatment other than general support is not indicated.Our experience does not accord with Dr. Crosby's dicta. Over the past six years we have personally observed 169 patients with AGL who have been treated within two weeks (usually within a few days) of the time of diagnosis. These patients have all been treated on studies of the Acute Leukemia Cooperative Chemotherapy Group B (ALB) with one or several of

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